Complement System

Complement System (Proteins, Antibodies, Genes and ELISA Kits)

C1QA C1QB C1QBP C1QC C1R C1RA C1S C3AR1 C5AR2 ITGB2 ITGAX MASP1 MASP2 MBL1 MBL2 CD46 CD55 CD59 CD93 CFB CFHR1
Browse full list of complement system related molecules

Complement System (Proteins, Antibodies, Genes and ELISA Kits)

C2 C5 C6 CFD CFH CLU SERPING1 VTN CR2 VSIG4 CALR

Complement Activation Pathways

Complement Activation Definition Complement Activation Alternative Pathway Complement Activation Lectin Pathway Serine Proteases of Complement Activation Pathway Complement Activation Classical Pathway

Complement System Component / Protein, Regulator and Receptor

Complement Receptors of Complement SystemComplement Component / Protein of Complement SystemComplement Regulator of Complement System: OthersComplement Regulator of Complement System: RCA/CCP family

Complement System Effector Functions

Complement Mediated OpsonizationComplement Mediated Cell LysisComplement Mediated PhagocytosisComplement Mediated InflammationComplement Mediated ChemotaxisComplement Mediated Antibody Formation

Complement System Role

Complement-Dependent Cytotoxicity / CDCComplement Evasion of PathogensComplement System and Direct InteractionsComplement Cascade and InhibitorsComplement System Function in Immune SystemComplement System and CoagulationComplement System and Toll-like Receptors / TLRsTherapeutic Target of Complement SystemComplement System and Antimicrobial Peptides/AMPs

Complement System and Diseases

Complement System and CancerComplement System and SchizophreniaComplement Receptor 1 / CR1 and Alzheimer's Disease / ADComplement System and Rheumatic DiseasesComplement System and Age-Related Macular Degeneration / AMDComplement System and Autoimmune Diseases

Complement System Deficiency Diseases

Classical Pathway DeficiencyAlternative Pathway DeficiencyComplement Receptor DeficiencyTotal Complement Activity / CH50 / CH100Mannose-Binding Lectin / MBL Pathway DeficiencyMembrane Attack Complex / MAC Deficiency

Complement System Structure

Complement Regulator StructureComplement Component / Protein StructureComplement Receptor StructureCollectins and Ficolins: Humoral Lectins of the Innate Immune SystemComplement Membrane Attack Complex / MAC

Complement Genetic Feature

Complement MHC Class III Gene ClusterComplement MAC Gene ClusterRegulator of complement activation / RCA Gene Cluster

Complement System Overview

What is Complement SystemHow Does Complement System WorkComplement Protein Fragment Nomenclature

Complement System Background

The complement system in blood plasma is a major mediator of innate immune defence. The function of complement is to recognize, then opsonize or lyse, particulate materials, including bacteria, yeasts and other microrganisms, host cell debris and altered host cells.

There are three ways in which the complement system protects against infection. First, it generates large numbers of activated complement proteins that bind covalently to pathogens, opsonizing them for engulfment by phagocytes bearing receptors for complement. Second, the small fragments of some complement proteins act as chemoattractants to recruit more phagocytes to the site of complement activation, and also to activate these phagocytes. Third, the terminal complement components damage certain bacteria by creating pores in the bacterial membrane.

Complement System References

1. Sim R B, et al. (2000). Serine proteases of the complement system. Biochemical Society Transactions, 28(5), 545-550.
2. Janeway Jr C A, et al. (2001). The immune system in health and disease.