Recombinant Protein

Sino Biological Inc. has over 10 years' experience of recombinant protein research and development, we have more than 6000 recombinant proteins in stock, covering most hot research areas, such as immune checkpoints, antibody drug targets, CAR-T cell therapy targets, Fc receptors, influenza viral proteins and cytokines.
Possessing high purity and validated bioactivity, Sino Biological recombinant proteins can support your scientific research from biopharmaceutical, protein structure, protein function, cell therapy to tool enzymes.

Index

Immune Checkpoint proteins   CAR-T cell therapy targets   Monoclonal Antibody Therapeutic Targets
Immune Checkpoint Proteins
Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……
CAR-T Cell Therapy Targets
Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……
Antibody Therapeutic Targets
Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……
Cytokine & Growth Factor   Fc Receptors   Biotinylated Protein
Cytokine & Growth Factor
Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……
Fc Receptors
Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……
Biotinylated Proteins
Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……

A Global Leader in Recombinant Protein R & D

Advanced Technology Platforms

  • • Five expression systems to support production
  • • Protein from multiple species to support animal models and drug development
  • • 70 qutomatic bioreactor
  • • 2L-2000L bioreactors to ensure high throughout manufacture
  • • GMP-level workshop
  • • Milligram level protein production

Strict quality control system

  • • Over 1000 methods for activity assay
  • • State-of-the-art analytical equipment set to ensure validated bioactivity
  • • N-terminal amino acid sequence analysis
  • • Better stability to ensure repeated experiments
  • • Qualified raw materials to ensure animal free

Premium Recombinant Protein Products

  • • >85% expressed by eukaryotic cell, close to natural structure
  • • Validated bioactivity
  • • Lower endotoxin: <0.1 EU per μg by LAL
  • • High purity: >95% by SDS-PAGE or HPLC
  • • Carrier Free: dissolved in PBS, without BSA
  • • 600+ GMP-level cytokines

Recombinant protein of high purity

The purity of human TNFα protein (Cat. No. GMP-10602-HNAE) was >97% determined by SEC-HPLC and >96% determined by SDS-PAGE

Fig .1 The purity of human TNFα protein (Cat. No. GMP-10602-HNAE) was >97% determined by SEC-HPLC and >96% determined by SDS-PAGE

Recombinant protein with high bioactivity

The comparison of VEGF165 bioactivity from Sino Biological (EC50=1.4 ng/ml) and another brand (EC50=4 ng/ml) in cell proliferation assays using HUVEC

Fig .2 The comparison of VEGF165 bioactivity from Sino Biological (EC50=1.4 ng/ml) and another brand (EC50=4 ng/ml) in cell proliferation assays using HUVEC.

Recombinant protein with high binding activity

The PD-1 (Cat. No. 10377-H03H) binding ability to PD-L2 was measured in a functional ELISA. ED50=0.94 μg/ml

Fig .3 The PD-1 (Cat. No. 10377-H03H) binding ability to PD-L2 was measured in a functional ELISA. ED50=0.94 μg/ml.

Custom recombinant protein produciton

Recombinant Protein Prodution Service description
We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.

Sino Biological has in-house capacity to support 1000-2000 recombinant protein development and bulk production per year. We could do rapid protein expression and purification process development and conduct process scaleup studies. We can meet protein production requirements for both high-throughput and large scale bulk productions. In the last couple of years, we have successfully produced over 6000 recombinant protein bulks (in the range of milligram to gram purified proteins). The unprecedented capacity can be utilized by our customers worldwide to accelerate their basic research, structural biology, product discovery, and product development.

We are committed to become the cost-effective centralized lab for recombinant protein and monoclonal antibody bulk production to serve the life science community and biotech industry worldwide. We strive to change the way the life science community and industry generating and sourcing their proteins.

More about Recombinant Protein Prodution Service

Contact us
Tel: 215-583-7898
Mail: order@sinobiological.com
Recombinant protein categories
• Cytokine Proteins
• Interleukin proteins
• Cell Therapy proteins
• B7 Family proteins
• Kinase proteins
• Biological Target proteins
• TNF Superfamily proteins
• Cancer proteins
• Benzonase Nuclease proteins
• Fc receptor proteins
• Growth Factor proteins
• Immunotherapy proteins
• Stem Cell proteins
• Protease proteins
• Diagnostic proteins
• TGF-beta Family proteins
• CD Molecule proteins
• Special proteins
• IgG-Fc Control proteins
• Receptor proteins
• Immune checkpoint proteins
• Viral proteins
• Enzyme proteins
• Biomarker proteins
• Fluorescence proteins
• Epigentic proteins
Other Elite Reagents
One-stop CAR-T reagents
Antibodies
• IHC antibody
• Elite Rabbit Mab
• ELISA kits
cDNA clones & Others
• GFP & OFP tagged cDNA clone
• Lentiviral ORF clone / plasmid
• Transfection reagents
• Protease & Nuclease